Water → 1-Bromo-2-chloro-4-methylsulfanyl-benzene

A solution of 1-bromo-2-chloro-4-fluorobenzene (7, 0.50 g, 2.39 mmol) and sodium thiomethoxide (0.17 g, 2.42 mmol) in DMSO (2.5 mL) was stirred at 100° C. for 1 h. The reaction mixture was added to 20 mL water with stirring, the aqueous mixture was extracted with ethyl acetate (2×20 mL) and the combined organic layers were dried over sodium sulfate, filtered and evaporated in vacuo. The title compound (0.62 g) was obtained as a colorless oil and was used in the next step without further purification.

1. extractionthe aqueous mixture was extracted with ethyl acetate (2×20 mL)
2. dry with materialthe combined organic layers were dried over sodium sulfate
3. filtrationfiltered
4. customevaporated in vacuo

ORD record

ord-977c56ca372744329ba1611e928a3e1f

Source dataset

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08912203B2