Methyl iodide → HCID 178503678, compound

Participants

Reaction Steps

To tert-butyl [(2S)-1-{[trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexyl]amino}-4-(methylsulfanyl)-1-oxobutan-2-yl]carbamate (760 mg) was added methyl iodide (3.5 mL), followed by stirring at room temperature overnight. Methyl iodide was evaporated under reduced pressure to obtain a desired compound [(3S)-3-[(tert-butoxycarbonyl)amino]-4-{[trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexyl]amino}-4-oxobutyl](dimethyl)sulfonium iodide (919 mg).

Provenance & Evidence