Trifluoroacetic acid → HCID 70863739, compound

Participants

Reaction Steps

A mixture of 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-(3,4-dimethoxy benzyl)-6-(morpholin-4-yl)pyrimidin-2-amine (5.3 g) and trifluoroacetic acid (0.82 mL) was stirred at 10 for 1 hour. The reaction mixture was neutralized by the addition of saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting solid was collected by filtration and washed with diisopropyl ether to obtain 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(morpholin-4-yl)pyrimidin-2-amine (1.36 g).

Provenance & Evidence