2-Methoxyethylamine → HCID 178496027, compound

Participants

Reaction Steps

To a 2-methoxyethanamine (1.9 mg) were added a solution of trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)cyclohexanecarboxylic acid (11.8 mg) and N,N-diisopropylethylamine (10.5 μL) in N,N-dimethylformamide (400 μL), and were added a solution of N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylMethanaminium hexafluorophosphoric acid (11.4 mg) in N,N-dimethylformamide (100 μL), followed by stirring at room temperature overnight. To the reaction solution were added water and chloroform, followed by liquid separation, and the organic layer was concentrated under reduced pressure. The residue was subjected to preparative purification with HPLC to obtain trans-4-({6-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-2-(morpholin-4-yl)pyrimidin-4-yl}oxy)-N-(2-methoxyethyl)cyclohexanecarboxamide (5.9 mg).

Provenance & Evidence