Tetrahydrofuran → 2-[(3-Ethynylphenyl)amino]ethanol

Participants

Reaction Steps

N-(2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl)-3-ethynylaniline (335 mg, 1.22 mmol) was treated with 1M TBAF in THF (1.5 mL, 1.5 mmol) at room temperature for 5 min. The volatiles were removed and the crude was dissolved in EtOAc (30 mL). The organic phase was washed with water (20 mL) and finally with brine, dried over sodium sulfate and evaporated to give the corresponding alcohol as brownish oil.

Provenance & Evidence