Potassium Carbonate → (4-Ethynylphenyl)(4-methylpiperazin-1-yl)methanone

Participants

Reaction Steps

(4-Methylpiperazin-1-yl){4-[(trimethylsilyl)ethynyl]phenyl}methanone (1.29 g, 4.26 mmol) in MeOH (20 mL) was treated with solid K2CO3 (0.118 g, 0.85 mmol). After stirring at room temperature for 3 h the volatiles were removed by evaporation, the residue was taken up with DCM (40 mL), washed with water (30 mL), brine, dried over sodium sulfate and evaporated. The crude was purified by flash chromatography on silica gel (DCM/MeOH 95/5) to afford the title compound as white solid (0.690 g, 71%).

Provenance & Evidence