3-Iodobenzoic acid → HCID 3409622, compound

Participants

Role	Name	HCID	Charge
Reactant	3-Iodobenzoic acid	HCID 12060	—
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 3409622	HCID 3409622	96.2%

Reaction Steps

1-Methylpiperazine (0.58 mL, 5.2 mmol), HOBt (0.70 g, 5.2 mmol) and EDCl (1.0 g, 5.2 mmol) were added to a solution of 3-iodobenzoic acid (1.0 g, 4.0 mmol) in dry DCM (40 mL). The mixture was stirred at room temperature for 16 h, washed with saturated aqueous sodium bicarbonate (30 mL), water (15 mL), brine, dried over sodium sulphate, and evaporated to afford the title compound (1.27 g, 96%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912200B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-c8f01a100bbe4fe19b3f14ed75bc3a39
Source note	uspto-grants-2014_12