Tetrabutylammonium Fluoride → HCID 71239652, compound

Participants

Reaction Steps

1M TBAF in THF (0.30 mL, 0.30 mmol) was added to a solution of (4-methylpiperazin-1-yl){3-[(trimethylsilyl)ethynyl]phenyl}methanone (90 mg, 0.30 mmol) in dry THF (1.5 mL) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated and the residue taken up with EtOAc (3 mL), washed with brine, dried over sodium sulfate and evaporated to afford the title compound (53 mg, 78%).

Provenance & Evidence