Vanillic Acid → HCID 71239650, compound

Participants

Role	Name	HCID	Charge
Reactant	Vanillic Acid	HCID 8468	—
Reactant	1-Methylpiperazine	HCID 53167	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 71239650	HCID 71239650	96%

Reaction Steps

1-Methylpiperazine (0.58 mL, 5.2 mmol), HOBt (0.70 g, 5.2 mmol.) and EDCl (1.0 g, 5.2 mmol) were added to a solution of 4-hydroxy-3-methoxybenzoic acid (0.69 g, 4.0 mmol.) in dry DCM (40 mL). The mixture was stirred at room temperature for 16 h, washed with saturated aqueous sodium bicarbonate (20 mL), brine, dried over sodium sulphate and evaporated to give the title compound (0.96 g, 96%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912200B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-d68c9c33cab04ecfb8a80352d6942e0e
Source note	uspto-grants-2014_12