Tetrabutylammonium Fluoride → HCID 71239570, compound

Participants

Reaction Steps

1M TBAF in THF (1.43 mL, 1.05 mmol) was added to a solution of {3-methoxy-4-[(trimethylsilyl)ethynyl]phenyl}(4-methylpiperazin-1-yl)methanone (0.450 g, 1.36 mmol) in dry THF (7 mL) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated and the residue taken up with EtOAc (30 mL), washed with brine, dried over sodium sulfate and evaporated to afford the title compound (0.263 g, 75%).

Provenance & Evidence