Propargyl bromide → 1-Methyl-4-(prop-2-yn-1-yl)piperazine

Participants

Reaction Steps

A solution of 3-bromoprop-1-yne (1.70 mL, 22.5 mmol in acetone (7 mL) was added to a suspension of 1-methylpiperazine (3.77 mL, 33.7 mmol) and K2CO3 (4.66 g, 33.7 mmol) in acetone (40 mL) at 0° C. The mixture was stirred at room temperature for 4 h and then filtered. The filtrate was evaporated to dryness and the residue was taken up with water (80 mL) and extracted with DCM (2×20 mL). The separated organic phase was washed with brine (3×5 mL), dried over sodium sulfate and evaporated to afford the title compound as brown oil (1.60 g, 51%).

Provenance & Evidence