HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57659335, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 70979820 | HCID 70979820 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57659335 | HCID 57659335 | 82% |
Reaction Steps
A solution of 5-(2-amino-pyrimidin-4-yl)-2-(5-chloro-2-methyl-phenyl)-1H-pyrrole-3-carboxylic acid (11.62 g, 30.4 mmol) in DMF (100 mL) and DIPEA (21.2 mL, 121.6 mmol) was stirred at 0° C. EDCl (11.64 g, 60.8 mmol) and HOBT.NH3 (9.38 g, 60.8 mmol) were added and the reaction mixture was stirred for 3 h at room temperature. The mixture was diluted with water and the resultant precipitate was collected by filtration to afford the title compound (8.17 g, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912200B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-bd75ed597ad548789932f22841c2960f |
| Source note | uspto-grants-2014_12 |