Ethanol → HCID 86725297, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-{2-amino-5-[(trimethylsilyl)ethynyl]pyrimidin-4-yl}-2-(5-chloro-2-methylphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-3-carboxylate (466 mg, 0.8 mmol) was treated with a 1.5 M solution of potassium hydroxide in 95% EtOH (5.33 mL, 8 mmol) and stirred at 50° C. overnight. After cooling, the residue was concentrated, dissolved in water and washed with DCM. The aqueous layer was acidified until pH<1 with the addition of 2 N HCl and extracted with EtOAc (3×). The combined organic layers were dried over Na2SO4 and the solvent evaporated under vacuum to obtain the title compound as an orange oil (367 mg, 95%).

Provenance & Evidence