Ethanol → HCID 71239580, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-(2-amino-5-bromopyrimidin-4-yl)-2-(5-chloro-2-ethylphenyl)-1H-pyrrole-3-carboxylate (400 mg, 0.89 mmol) was treated with a 1.5 M solution of potassium hydroxide in 95% EtOH (11.86 mL, 20 eq) under reflux overnight. After cooling, the residue was concentrated, dissolved in water and washed with DCM. To the aqueous phase cooled to 5° C., a solution of 2 N HCl was added, under agitation. The resultant precipitate was collected by filtration to give the title compound (356 mg, 95%).

Provenance & Evidence