HCID 57963053, compound → HCID 57963226, compound

HRID 1403261Notes

Reaction equation

HRID 1403261 reaction equation
C1(S([N:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([O:19][CH3:20])[C:13]=3[C:12](I)=[CH:11]2)(=O)=O)C=CC=CC=1.C(OC(=O)[N:28]([CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[Cl:45])[C:29]1[CH:34]=[CH:33][C:32]([CH:35]=O)=[C:31]([F:37])[N:30]=1)(C)(C)C>>[Cl:45][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=1[CH2:38][NH:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:12]2[C:13]3[C:18]([O:19][CH3:20])=[N:17][CH:16]=[N:15][C:14]=3[NH:10][CH:11]=2)=[C:31]([F:37])[N:30]=1

Participants

3

Reactant 2

HCID 57963053HCID 57963053, compoundHCID 57963111HCID 57963111, compound

Product 1

HCID 57963226HCID 57963226, compound

Procedure

(2-Chloro-benzyl)-[6-fluoro-5-(4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-pyridin-2-yl]-amine P-0090 was prepared in three steps from 7-benzenesulfonyl-5-iodo-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine 42 and (2-chloro-benzyl)-(6-fluoro-5-formyl-pyridin-2-yl)-carbamic acid tert-butyl ester 19 as shown in Scheme 9.

Sources & evidence

ORD record
ord-5c79bc01b6104eacbebe9fa590f04c53
Source dataset
uspto-grants-2014_12
Patent number
US08912204B2

Reaction notes

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