Potassium Phosphate, Tribasic → HCID 70664642, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-chloro-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylate (Scheme I, 120 mg, 0.41 mmol) in dioxane (3 mL) was added K3PO4 (257 mg, 1.22 mmol), 6-methoxypyridin-3-ylboronic acid (187 mg, 1.22 mmol) and Pd(PPh3)4 (23.54 mg, 0.02 mmol) with stirring for 1 h at 90° C. in an oil bath with an inert atmosphere of nitrogen. The reaction mixture was concentrated under vacuum to get a residue, which was purified by a silica gel column with 1%-2% ethyl acetate in petroleum ether to afford methyl 3-(isopropyl(methyl)amino)-2-(6-methoxypyridin-3-yl)quinoxaline-6-carboxylate as a light yellow solid (120 mg, 80%).

Provenance & Evidence