Sodium Hydroxide → HCID 50991567, compound

Participants

Reaction Steps

To a solution of methyl 3-(isopropyl(methyl)amino)-2-(6-methoxypyridin-3-yl)quinoxaline-6-carboxylate (140 mg, 0.38 mmol) in methanol (25 mL) was added sodium hydroxide (45.9 mg, 1.15 mmol) with stirring overnight at room temperature. The reaction mixture was concentrated under vacuum, dissolved in water (30 mL) and adjusted to pH 6 with HCl (3N). The product were collected by filtration to afford 3-(isopropyl(methyl)amino)-2-(6-methoxypyridin-3-yl)quinoxaline-6-carboxylic acid as a light yellow solid (105 mg, 78%). LC/MS (ES, m/z): [M+H]+ 352.0

Provenance & Evidence