HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-chloro-2-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Chlorosalicylic acid | HCID 78782 | — |
| Product | Methyl 4-chloro-2-hydroxybenzoate | HCID 327085 | 95% |
Reaction Steps
To a solution of 4-chloro-2-hydroxybenzoic acid (20 g, 115.90 mmol) in methanol (500 mL) was added thionyl chloride (26 mL). After refluxing for 3 h, the reaction mixture was concentrated under vacuum, dissolved in petroleum ether (300 mL) and filtered to give methyl 4-chloro-2-hydroxybenzoate as a white solid (21 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912188B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5a1348a9fca84f868cfbd92c02a77418 |
| Source note | uspto-grants-2014_12 |