HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1403448Generated: October 31, 2026
Diisopropylethylamine → (S)-methyl 3-(2-methylpiperidin-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate
https://huagongshe.com/reaction/1403448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-(+)-2-Methylpiperidine | HCID 6427443 | — |
| Reactant | Methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate | HCID 68194304 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (S)-methyl 3-(2-methylpiperidin-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate | HCID 70654252 | 79% |
Reaction Steps
To a solution of methyl 3-chloro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (200 mg, 0.84 mmol) in DMSO (2 mL) was added (S)-2-methylpiperidine (166 mg, 1.7 mmol) and DIEA (217 mg, 1.7 mmol). The resulting solution was stirred at 70° C. for 3 h and then quenched by water (10 mL), the solids were collected by filtration to afford (S)-methyl 3-(2-methylpiperidin-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a light yellow solid (200 mg, 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08912188B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-89067ae7c94e4bfda15de37095529456 |
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| Source note | uspto-grants-2014_12 |
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