Sodium Hydroxide → HCID 70664914, compound

Participants

Reaction Steps

To a solution of methyl 2-(1-benzofuran-3-yl)-3-[(2S)-2-methylpyrrolidin-1-yl]quinoxaline-6-carboxylate (80 mg, 0.21 mmol) in methanol (40 mL) and water (1 mL) was added sodium hydroxide (33 mg, 0.83 mmol) with stirring overnight at room temperature. The resulting mixture was concentrated under vacuum, dissolved in water (50 ml) adjusted to pH 6 with HCl (3N), and collected by filtration to give 2-(1-benzofuran-3-yl)-3-[(2S)-2-methylpyrrolidin-1-yl]quinoxaline-6-carboxylic acid as a yellow solid (60.1 mg, 78%).

Provenance & Evidence