Sodium Hydroxide → HCID 70664981, compound

Participants

Reaction Steps

To a solution of methyl 3-[methyl(propan-2-yl)amino]-2-(1-phenyl-1H-pyrazol-4-yl)quinoxaline-6-carboxylate (80 mg, 0.20 mmol) in methanol (25 ml) and chloroform (5 ml) was added sodium hydroxide (24 mg, 0.60 mmol) with stirring overnight at room temperature. The reaction mixture was concentrated under vacuum, dissolved in water (15 ml), and the pH adjusted to 5 with HCl (3N) to give the precipitate, which was collected by filtration to afford 3-[methyl(propan-2-yl)amino]-2-(1-phenyl-1H-pyrazol-4-yl)quinoxaline-6-carboxylic acid (56 mg, 73%).

Provenance & Evidence