Methanol → HCID 70664661, compound

Participants

Reaction Steps

The solution of methyl 3-((1-(tert-butoxycarbonyl)piperidin-4-yl)(methyl)amino)-2-(4-fluorophenyl)quinoxaline-6-carboxylate (210 mg, crude) in hydrogen chloride(g)/MeOH (50 mL) was stirred overnight at room temperature and then concentrated in vacuo. The residue was dissolved in water (50 mL) and adjusted to pH 8 with sodium bicarbonate, extracted with dichloromethane (5×30 mL), dried over anhydrous magnesium sulfate and concentrated in vacuo. The product was precipitated by the addition ether (20 mL) to afford methyl 2-(4-fluorophenyl)-3-(methyl(piperidin-4-yl)amino)quinoxaline-6-carboxylate as a yellow solid (100 mg).

Provenance & Evidence