Potassium Nitrate → Methyl 4-fluoro-2-methoxy-5-nitrobenzoate

HRID 1403584노트

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HRID 1403584 반응식
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.[N+:14]([O-])([O-:16])=[O:15].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:11]([N+:14]([O-:16])=[O:15])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 10241478Methyl 4-fluoro-2-methoxybenzoate

생성물 1

HCID 10014029Methyl 4-fluoro-2-methoxy-5-nitrobenzoate수율 64.3%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

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온도
12.5 °C

실험 절차

To a solution of methyl 4-fluoro-2-methoxybenzoate (50 g, 271.50 mmol) in sulfuric acid (150 mL) was added a solution of potassium nitrate (35.6 g, 352.48 mmol) in sulfuric acid (30 mL) dropwise with stirring for 45 min at 0-25° C. in an ice/water bath. The reaction was then quenched by the addition of water/ice. The solids were collected by filtration to afford methyl 4-fluoro-2-methoxy-5-nitrobenzoate as a white solid (40.0 g, 64%).

후처리

  1. customThe reaction was then quenched by the addition of water/ice
  2. filtrationThe solids were collected by filtration

출처 및 근거

ORD 기록
ord-6c003e5b3fbc4abab3a90cb706df54a9
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08912188B2

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