Sodium Hydroxide → HCID 70665026, compound

Participants

Reaction Steps

To a solution of methyl 3-(2-ethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate (45 mg, 0.11 mmol) in methanol (15 mL) was added sodium hydroxide (10 mg, 0.25 mmol) in water (1 mL). The resulting solution was stirred overnight at room temperature and concentrated in vacuo. The residue was dissolved in water (3 mL), adjusted to pH 5 with hydrochloric acid (3M), and collected by filtration to afford 3-(2-ethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid as a yellow solid (23.3 mg, 54%).

Provenance & Evidence