HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate → HCID 70664987, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate | HCID 77231184 | — |
| Solvent | 1-Phenethylamine, (-)- | HCID 75818 | — |
| Product | HCID 70664987 | HCID 70664987 | 87.4% |
Reaction Steps
The solution of methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate (180 mg, 0.57 mmol) in (S)-1-phenylethanamine (2 mL) was stirred overnight at 95° C., and then purified via silica gel column chromatography (1%-2% ethyl acetate in petroleum ether) to afford (S)-methyl 2-(4-fluorophenyl)-3-(1-phenylethylamino)quinoxaline-6-carboxylate as yellow oil (100 mg, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912188B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-c24470b8264841c2b9b0ed74344ed6ce |
| Source note | uspto-grants-2014_12 |