HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-(5'-Bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | 1-(Piperidin-4-yl)ethan-1-ol | HCID 338321 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(5'-Bromo-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)ethanol | HCID 66660771 | — |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
An autoclave is charged with 11 g (46.43 mmol) of 2,5-dibromopyridine, 6 g (46.43 mmol) of piperidin-4-ylethanol and 6.74 g (48.76 mmol) of potassium carbonate in 8 ml of DMSO. This charge is subsequently heated at 160° C. for 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912218B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-48f558b0fadc4f9990f8fbd5ff26e7c3 |
| Source note | uspto-grants-2014_12 |