Potassium Carbonate → HCID 67130432, compound

Participants

Reaction Steps

Under an inert atmosphere, 3.6 g (12.62 mmol) of 2-(6′-bromo-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl)ethanol (WO2004/099176), 3.53 g (25.25 mmol) of 4-fluorophenylboronic acid, 5.23 g (37.87 mmol) of potassium carbonate and 4.88 g (15.15 mmol) of tetrabutylammonium bromide in suspension in 20 ml of water are introduced. Subsequently 0.142 g (0.63 mmol) of Pd(OAc)2 is added. The reaction mixture is subsequently heated at reflux for 24 hours.

Provenance & Evidence