HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl triflate → 3-[(4-Fluoro-benzyl)-isobutyl-sulfamoyl]-1-methyl-3H-imidazol-1-ium triflate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl triflate | HCID 9526 | — |
| Reactant | Imidazole-1-sulfonic acid (4-fluoro-benzyl)-isobutyl-amide | HCID 90437309 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[(4-Fluoro-benzyl)-isobutyl-sulfamoyl]-1-methyl-3H-imidazol-1-ium triflate | HCID 90410875 | — |
Reaction Steps
A solution of imidazole-1-sulfonic acid (4-fluoro-benzyl)-isobutyl-amide (260 mg, 835 μmol) in DCM (5 mL) at 0° C. was treated dropwise with methyl trifluoromethane sulfonate (101 μL, 918 μmol) and stirred cold for 2 hours. The mixture was concentrated under vacuum and used immediately in the next step. LCMS (m/z, Method A) ES+ 326.0 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912219B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-35404741c7cf4108bf15c0a324d93d00 |
| Source note | uspto-grants-2014_12 |