HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Phenyl 1H-imidazole-1-sulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-sulphonylbis-1H-imidazole | HCID 81609 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Phenyl 1H-imidazole-1-sulfonate | HCID 90409877 | 60.2% |
Reaction Steps
To a solution of phenol (400 mg, 4.3 mmol) in THF (25 mL) was added 1,1′-sulfonyldiimidazole (1.0 g, 5.1 mmol) and Cs2CO3 (2.8 g, 8.5 mmol). The mixture was stirred at ambient temperature for 16 h. The solvent was removed and the residue was purified by silica gel chromatography to yield the title compound (580 mg, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912219B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-3d58a4fabebf41b3a136f564eca7e95a |
| Source note | uspto-grants-2014_12 |