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Triethylamine → 1-Benzyl-3-methyl-5-nitroindazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| 反応物 | 1-(2-Fluoro-5-nitrophenyl)ethan-1-one | HCID 2781067 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Benzyl-3-methyl-5-nitroindazole | HCID 21952162 | — |
反応手順
2-Fluoro-5-nitroacetophenone (H. Sato et al, Bioorganic and Medicinal Chemistry Letters, 5(3), 233-236, 1995) (0.24 g) was treated with triethylamine (0.73 ml) and benzyl hydrazine dihydrochloride (0.255 g) in ethanol (20 ml) at reflux under N2 for 8 days. The mixture was cooled and the solid 1-benzyl-3-methyl-5-nitroindazole (0.16 g) was collected by filtration; m/z (M+1)+ 268.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08912205B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-d8932f84c1fe4c04af2d6fbe07f28d8e |
| 出典メモ | uspto-grants-2014_12 |