1-(Phenylmethyl)-1H-indazol-5-amine → (1-benzyl-1H-indazol-5-yl)-(6-iodo-7-fluoroquinazolin-4-yl)-amine hydrochloride

HRID 1403759Notes

Reaction equation

HRID 1403759 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][C:19]1[C:28]2[C:23](=[CH:24][C:25]([F:30])=[C:26]([I:29])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[ClH:18].[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:19]3[C:28]4[C:23](=[CH:24][C:25]([F:30])=[C:26]([I:29])[CH:27]=4)[N:22]=[CH:21][N:20]=3)=[CH:14][CH:15]=2)[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 2120691-(Phenylmethyl)-1H-indazol-5-amineHCID 219520064-Chloro-7-fluoro-6-iodoquinazoline

Product 1

HCID 21952244(1-benzyl-1H-indazol-5-yl)-(6-iodo-7-fluoroquinazolin-4-yl)-amine hydrochloride

Procedure

Prepared according to Procedure A from 1-benzyl-1H-indazol-5-ylamine and 4-chloro-6-iodo-7-fluoroquinazoline. δ H NMR (400 MHz, DMSO-d6): 11.55 (s, 1H), 9.41 (d, 1H), 8.8 (s, 1H), 8.18 (s, 1H), 8.05 (d, 1H), 7.78 (d, 1H), 7.69 (d, 1H), 7.61 (m, 1H), 7.29 (m, 2H), 7.23 (m, 3H), 5.67 (s, 2H). ESI-MS m/z 496 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-52d0fcce2dc3496eb39bf3e08f40a1f5
Source dataset
uspto-grants-2014_12
Patent number
US08912205B2

Reaction notes

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