Acetic Anhydride → HCID 86654326, compound

HRID 1404087Notes

Reaction equation

HRID 1404087 reaction equation
[Br:1][C:2]1[C:8]([O:9][CH3:10])=[C:7]([Br:11])[CH:6]=[C:5]([F:12])[C:3]=1[NH2:4].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[Br:1][C:2]1[C:8]([O:9][CH3:10])=[C:7]([Br:11])[CH:6]=[C:5]([F:12])[C:3]=1[NH:4][C:13](=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 86654325HCID 86654325, compound

Product 1

HCID 86654326HCID 86654326, compoundYield 79.2%

Procedure

Compound 8-5 (212.7 g, 0.711 mol) was added to acetic anhydride (200 mL) in one portion at 20° C. The reaction mixture was stirred for 30 minutes and then was filtered to get 8-6 (192 g, 79.2%) as a white solid.

Workup

  1. filtrationwas filtered

Sources & evidence

ORD record
ord-1ce35c1fb7da4a5cab3562920946b611
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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