2-(4-Benzyloxy-5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine → 2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine

HRID 1404093Notes

Reaction equation

HRID 1404093 reaction equation
C(OC1C(F)=CC=C2C=1C(CCN(C)C)=CN2)C1C=CC=CC=1.[F:24][C:25]1[CH:26]=[C:27]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:28]([O:41][CH3:42])=[C:29]2[C:33]=1[N:32]([CH3:34])[CH:31]=[C:30]2[CH2:35][C:36]([N:38]([CH3:40])[CH3:39])=O>>[F:24][C:25]1[CH:26]=[C:27]([C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=2)[C:28]([O:41][CH3:42])=[C:29]2[C:33]=1[N:32]([CH3:34])[CH:31]=[C:30]2[CH2:35][CH2:36][N:38]([CH3:39])[CH3:40]

Participants

3

Reactant 2

HCID 669270882-(4-Benzyloxy-5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamineHCID 669270952-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Product 1

HCID 509954512-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylethanamine

Procedure

Following the procedure used to prepare compound 1-7a (step 6 scheme 1), compound 8-12 gave compound 8-13

Sources & evidence

ORD record
ord-be86a368de764e148b8b7376800c896b
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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