Dimethylformamide → HCID 58303957, compound

Participants

Reaction Steps

To the solution of 9-1 (prepared according to the same procedure of ethyl 2-(5-bromo-7-fluoro-4-methoxy-1H-indol-3-yl)acetate) (2.0 g, 6.3 mmol) in anhydrous DMF (15 mL) was added KOH (1.12 g, 20 mmol), and iodomethane (1.8 g, 12.7 mmol). The mixture was stirred for 1 h at room temperature. After quenching with water, the reaction mixture was extracted with ethyl acetate (150 mL×3). The combined organic layers were dried over anhydrous sodium sulfate. After filtration and concentration, a residue 9-2 (3.0 g, crude) was obtained as yellow oil which was used for the next step without further purification.

Provenance & Evidence