HCID 58303866, compound → HCID 50997588, compound

Participants

Reaction Steps

Following the procedure (step 6, scheme 17) used to prepare compound 17-7, compound 18-1 gave compound 18-2 in 72% yield as a colorless oil, which was converted to the hydrochloride salt. 1H NMR (DMSO-d6, 300 MHz) δ (ppm) (HCl salt): 9.92 (br, 1H), 7.23-7.32 (m, 5H), 7.21 (s, 1H), 7.10 (dd, J=9.1, 4.1 Hz, 1H), 7.04 (dd, J=12.1, 8.8 Hz, 1H), 4.40 (td, J=7.4, 1.6 Hz, 2H), 3.70 (s, 3H), 3.16-3.21 (m, 2H), 3.11 (t, J=7.1 Hz, 2H), 3.00-3.06 (m, 2H), 2.73 (s, 6H). LRMS: calc 340.2 found 341.2 [MH]+.

Provenance & Evidence