HCID 58303860, compound → HCID 58303981, compound

Participants

Reaction Steps

Following the procedure (step 4, scheme 17) used to prepare compound 17-5, compound 19-2 was used as starting material, using Pd(OH)2/C (20%) as source of Pd to afford 19-3 (45% yield) as a white solid. The compound was then converted to the hydrochloride salt. 1H NMR (D2O, 300 MHz) δ (ppm) (HCl salt): 7.06 (s, 1H), 7.03 (dd, J=11.2, 9.1 Hz, 1H), 6.89 (dd, J=9.1, 3.6 Hz, 1H), 4.10 (dd, J=15.1, 4.1 Hz, 1H), 4.04 (dd, J=15.1, 7.7 Hz, 1H), 3.75-3.84 (m, 2H), 3.27-3.36 (m, 3H), 3.12-3.17 (m, 2H), 1.63-1.79 (m, 2H), 1.40-1.50 (m, 3H), 1.20-1.28 (m, 1H). LRMS: calc 292.2 found 293.1 [MH]+.

Provenance & Evidence