HCID 58303927, compound → HCID 58304034, compound

HRID 1404111Notes

Reaction equation

HRID 1404111 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[C:7]([O:13][CH3:14])[CH:8]=[CH:9][C:10]=2[F:12])[C:5]([CH2:15][CH2:16][OH:17])=[CH:4]1)C.F[C:19]1[CH:20]=[C:21]([CH2:33][CH2:34]C2C=CC=CC=2)[C:22](OC)=[C:23]2[C:27]=1NC=C2CCO>>[F:12][C:10]1[CH:9]=[C:8]([CH2:34][CH2:33][C:21]2[CH:22]=[CH:23][CH:27]=[CH:19][CH:20]=2)[C:7]([O:13][CH3:14])=[C:6]2[C:11]=1[N:3]([CH3:1])[CH:4]=[C:5]2[CH2:15][CH2:16][OH:17]

Participants

3

Reactant 2

HCID 58303927HCID 58303927, compoundHCID 58303950HCID 58303950, compound

Product 1

HCID 58304034HCID 58304034, compoundYield 69%

Procedure

Following the procedure (step 2, scheme 20) used to prepare compound 20-3, compound 23-2 gave compound 23-3 in 69% yield as a colorless oil. 1H NMR (CDCl3, 300 MHz) δ ppm: 7.22-7.29 (m, 5H), 6.79 (s, 1H), 6.70 (d, J=12.9 Hz, 1H), 3.90 (d, J=1.92 Hz, 3H), 3.84-3.89 (m, 2H), 3.74 (s, 3H), 3.05 (d, J=6.0 Hz, 2H), 2.9-2.96 (m, 4H), 2.11 (t, J=5.8 Hz, 1H).

Sources & evidence

ORD record
ord-8add7a928f8b433aac3e044c4a6d088d
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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