HCID 86654328, compound → HCID 58303857, compound

Participants

Reaction Steps

A mixture of 25-2 (78.6 mg, 0.25 mmol) and Pd/C (5%, 50 mg) in MeOH was purged with nitrogen and hydrogen, and then the reaction was stirred at room temperature. After 6 h, the reaction mixture was filtered and concentrated to give the compound 25-3 as a pale yellow semi-solid (67 mg), which was used for the next step without purification. 1H NMR (CDCl, 300 MHz) δ (ppm) 6.82 (d, J=8.0 Hz, 1H), 6.64 (s, 1H), 6.37 (d, J=8.0 Hz, 1H), 3.93 (s, 3H), 3.87 (s, 3H), 3.28-3.34 (m, 2H), 2.99-3.05 (m, 2H), 2.57-2.69 (m, 4H), 2.35 (s, 6H).

Provenance & Evidence