HCID 58303950, compound → HCID 50995818, compound

HRID 1404115Notes

Reaction equation

HRID 1404115 reaction equation
FC1C=C(CCC2C=CC=CC=2)C(OC)=C2C=1NC=C2CCO.[CH2:24]([NH:31][CH2:32][CH2:33][C:34]1[C:42]2[C:37](=[CH:38][C:39]([F:51])=[CH:40][C:41]=2[O:43]CC2C=CC=CC=2)[N:36]([CH2:52][CH3:53])[CH:35]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([NH:31][CH2:32][CH2:33][C:34]1[C:42]2[C:41]([OH:43])=[CH:40][C:39]([F:51])=[CH:38][C:37]=2[N:36]([CH2:52][CH3:53])[CH:35]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 58303950HCID 58303950, compoundHCID 58304015HCID 58304015, compound

Product 1

HCID 50995818HCID 50995818, compoundYield 37%

Procedure

Following the procedure (step 2-1, scheme 23) used to prepare compound 23-2, compound 26-7 gave compound 26-8 in 37% yield (67.5 mg) as off-white solid. 1H NMR (300 MHz, MeOD-d6) δ (ppm): 7.41 (d, J=20.1 Hz, 5H), 6.96 (s, 1H), 6.59 (dd, J=9.9, 2.1 Hz, 1H), 6.19 (dd, J=11.2, 2.0 Hz, 1H), 4.20 (s, 2H), 4.05 (q, J=7.3 Hz, 2H), 3.37 (dd, J=13.4, 6.1 Hz, 2H), 3.26-3.16 (m, 2H), 1.37 (t, J=7.2 Hz, 3H). LRMS: calc 312.16. found 313.1 [MH]+.

Sources & evidence

ORD record
ord-0b7d7bb4295a4dd0a172b46378e395d7
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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