Hydrochloric Acid → HCID 58303855, compound

Participants

Reaction Steps

To a solution of 30-4 (22.9 g, 77 mmol) in ethanol (100 mL) at room temperature was added concentrated HCl (74 mL) and SnCl2 (44 g, 231 mmol). The mixture was allowed to stir at room temperature for 4 hours. The reaction mixture was poured into water and extracted with ethyl acetate (3×150 mL), the organic layer was combined and was concentrated under vacuum to get a crude product which was purified on silica gel column chromatography eluting with petroleum ether/ethyl acetate (5:1 to 1:1) to afford 30-5 (16 g, 78%) as a white solid. LRMS: calc 266.9 and found: 267.9 [M+1].

Provenance & Evidence