Methanol → HCID 58303877, compound

Participants

Reaction Steps

To a solution of 30-9 (582 mg, 6.4 mmol) in CH3OH (20 mL) was added SOCl2 (1 mL). The mixture was refluxed for 2 h before it was cooled to room temperature, the solvent was removed under reduce pressure. The resulting residue was partitioned between water (30 mL) and ethyl acetate (30 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3×20 mL). The combined organic layers were combined, washed with brine (3×20 mL), dried over Na2SO4, filtered and concentrated to afford 30-10 (500 mg, 82%) as a light yellow solid. LRMS: calc 285.0 and found: 286.1 [M+1].

Provenance & Evidence