HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 66927211, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58303999 | HCID 58303999 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66927211 | HCID 66927211 | 69% |
Reaction Steps
A solution of 30-13 (30 mg, 0.12 mmol), HATU (76 mg, 0.2 mmol), DIPEA (39 mg, 0.3 mmol) and phenylmethanamine (17 mg, 0.16 mmol) in THF (5 mL) was stirred at room temperature overnight. Water (5 mL) and ethyl acetate (10 mL) were added to the mixture. The organic layer was separated, washed with brine (3×20 mL), dried over MgSO4, filtered and evaporated to give a crude product, which was purified by preparative TLC (petroleum ether/ethyl acetate=1:1) to afford 30-14 (28 mg, 69%) as a light yellow solid. LRMS: calc 340.2 and found: 341.1 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912220B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-33ec4d493f244186b824691ac07963f2 |
| Source note | uspto-grants-2014_12 |