HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid → 2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)-N-methyl acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid | HCID 58304036 | — |
| Reactant | 2-(4-(benzyloxy)-1-ethyl-6-fluoro-1H-indol-3-yl)-1-(isoindolin-2-yl)ethanone | HCID 67235028 | — |
| Product | 2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)-N-methyl acetamide | HCID 58304022 | 96% |
Reaction Steps
Following the procedure (step 1, scheme 31) used to prepare compound 31-2, compound 33-4 gave compound 33-5 in 96% yield as a yellow solid. LRMS: calc 404.0 and found: 405.0 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912220B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a327eb772e3e4ea384b063bf6cf40c4f |
| Source note | uspto-grants-2014_12 |