反应详情

A mixture of 33-6 (40 mg, 0.17 mmol), 1-(bromomethyl)-3-chlorobenzene (35 mg, 0.17 mmol) and Cesium carbonate (166 mg, 0.51 mmol) in acetonitrile (20 mL) was refluxed for 2 h. After cooled to room temperature, the mixture was filtered and the filtrate was evaporated under vacuum. The resulting residue was purified by Preparative TLC (petroleum ether/ethyl acetate=1:3) to give 33-7 (50 mg, 82%) as a white solid. LRMS: calc 360.1 and found: 361.1 [M+1].

1. temperaturewas refluxed for 2 h
2. filtrationthe mixture was filtered
3. customthe filtrate was evaporated under vacuum
4. customThe resulting residue was purified by Preparative TLC (petroleum ether/ethyl acetate=1:3)