HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(benzyloxy)-7-bromo-5-fluoro-1H-indole → 2-(4-(benzyloxy)-7-bromo-5-fluoro-1H-indol-3-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(benzyloxy)-7-bromo-5-fluoro-1H-indole | HCID 58303856 | — |
| Reactant | 2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid | HCID 58304036 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 2-(4-(benzyloxy)-7-bromo-5-fluoro-1H-indol-3-yl)acetic acid | HCID 58303897 | 58% |
Reaction Steps
Following the procedure (step 3, scheme 33) used to prepare compound 33-4, compound 17-1 gave compound 34-2 in 58% yield as a yellow solid after column chromatography on silica gel eluting with dichloromethane/methanol (5:1). LRMS: calc 377.0 and found: 378.0 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912220B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-e55f0157675240cea71a03970661c355 |
| Source note | uspto-grants-2014_12 |