Potassium Carbonate → 2-(1-ethyl-4-methoxy-6-phenyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide

Participants

Reaction Conditions

Reaction Steps

To a sealable vessel was added 36-3 (100 mg, 0.28 mmol), phenylboronic acid (1042 mg, 0.86 mmol), Pd(PPh3)4 (66 mg, 10 mol %), and potassium carbonate (117 mg, 0.85 mmol). Dioxane (1.5 mL) was added and the reaction heated at 100° C. two days. The reaction mixture was diluted with ethyl acetate, filtered through celite and concentrated. The resulting residue was purified on silica gel column chromatography eluting with hexanes/ethylacetate (50-100%) to afford 79 mg of 36-4. LCMS: calc 350.2 and found: 351.1 [MH]+.

Provenance & Evidence