反应详情

Following the procedure (step 3 scheme 31 used to prepare compound 31-4 compound 38-3 gave compound 38-4 (113 mg, 59%) as a light tan-colored solid. 1H NMR (300 MHz, MeOD-d6): δ (ppm) 6.80 (s, 1H), 6.49 (dd, J=10.0, 2.1 Hz, 1H), 6.13 (dd, J=11.4, 2.1 Hz, 1H), 4.01 (q, J=7.2 Hz, 2H), 3.53-3.40 (m, 2H), 3.05 (d, J=11.4 Hz, 1H), 2.55 (dt, J=23.0, 11.7 Hz, 2H), 2.14 (dd, J=8.8, 6.1 Hz, 1H), 1.85-1.56 (m, 3H), 1.34 (t, J=7.2 Hz, 3H). LCMS: calc 262.1 and found: 263.1 [MH]+.