HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(1-ethyl-6-fluoro-4-methoxy-1H-indol-3-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-ethyl-6-fluoro-3-(2-hydroxyethyl)-1H-indol-4-ol | HCID 66927201 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(1-ethyl-6-fluoro-4-methoxy-1H-indol-3-yl)ethanol | HCID 66927082 | 92.2% |
Reaction Steps
39-2 (318 mg, 1.43 mmol) was dissolved in DMF (5 mL) and then potassium carbonate (236 mg, 1.71 mmol) and methyl iodide (98 uL, 1.56 mmol) were added. The reaction mixture was stirred at room temperature overnight, concentrated under vacuum and then water added. A solid was filtered to afford 39-3 (313 mg, 90%) as a light purple solid. LCMS: calc 326.2. found 327.1 [MH]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912220B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2dc35020ef594c509e316379bd578231 |
| Source note | uspto-grants-2014_12 |