2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid → 2-(6-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	2-(4-(benzyloxy)-7-bromo-5-fluoro-1-methyl-1H-indol-3-yl)acetic acid	HCID 58304036	—
Reactant	6-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole	HCID 66927219	—
Product	2-(6-bromo-7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acid	HCID 66927321	74%

Reaction Steps

Following the procedure (step 3, scheme 333) used to prepare compound 33-4, compound 40-3 gave compound 40-4 in 74% yield as a yellow solid. LCMS: calc 353.0 found 353.9 [MH]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912220B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-3286cd95e0a848d9a8a3e2ce719621ac
Source note	uspto-grants-2014_12