2-(4-Benzyloxy-5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine → 2-(7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)ethanamine

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Reaction Steps

Following the procedure (step 6, scheme 1) used to prepare compound 1-7a, compound 40-6 gave compound 40-7 (5 mg, 9%) as yellow oil. 1H NMR (300 MHz, MeOD-d6): δ (ppm) 6.87 (s, 1H), 6.73 (d, J=8.8 Hz, 1H), 6.61 (d, J=8.8 Hz, 1H), 4.26-4.24 (m, 2H), 4.16-1.15 (m, 2H), 3.91 (t, J=7.2 Hz, 2H), 3.13 (t, J=7.2 Hz, 2H), 3.02 (t, J=7.2 Hz, 2H), 1.71 (q, J=7.2 Hz, 2H), 0.80 (t, J=7.2 Hz, 3H). LCMS: calc 260.2 found 261.1 [MH]+.

Provenance & Evidence